Piacenza (Italian: [pjaˈtʃɛntsa] (listen); Piacentino: Piaṡëinsa [pi.aˈzəi̯sɐ]; Latin: Placentia) is a city and comune in the Emilia-Romagna region of northern Italy, and the capital of the eponymous province. As of 2022, Piacenza is the ninth largest city in the region by population, with over 102,000 inhabitants.

Westernmost major city of the region of Emilia-Romagna, it has strong relations with Lombardy, with which it borders, and in particular with Milan. It was once defined by Leonardo da Vinci as "Land of passage", in his Codex Atlanticus, by virtue of its crucial geographical location. Piacenza integrates characteristics of the nearby Ligurian and Piedmontese territories added to a prevalent Lombard influence, favored by communications with the nearby metropolis, which attenuate its Emilian footprint.

Piacenza is located at a major crossroads at the intersection of Route E35/A1 between Bologna and Milan, and Route E70/A21 between Brescia and Turin. Piacenza is also at the confluence of the Trebbia, draining the northern Apennine Mountains, and the Po, draining to the east. Piacenza also hosts two universities, Università Cattolica del Sacro Cuore, Polytechnic University of Milan and University of Parma.